THE LXR-IDOL AXIS DEFINES A CLATHRIN-, CAVEOLAE-, AND DYNAMIN-INDEPENDENT ENDOCYTIC ROUTE FOR LDLR INTERNALIZATION AND LYSOSOMAL DEGRADATION

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR).Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma liftmaster expansion board membrane.Activation of the sterol-sensing nuclear receptors liver X receptors (L

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Chromatin dynamics at the maternal to zygotic transition: recent advances from the zebrafish model [version 1; peer review: 2 approved]

Early animal development is characterized by intense reorganization of the embryonic genome, including large-scale changes in chromatin structure pink ps5 controller skin and in the DNA and histone modifications that help shape this structure.Particularly profound shifts in the chromatin landscape are associated with the maternal-to-zygotic transit

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Subjecting Dams to Early Life Stress and Perinatal Fluoxetine Treatment Differentially Alters Social Behavior in Young and Adult Rat Offspring

Recently, the putative association between selective serotonin reuptake inhibitor (SSRI) exposure during pregnancy and the development of social disorders in children has gained increased attention.However, clinical studies struggle with the confounding effects of maternal depression typically co-occurring with antidepressant treatment.Furthermore,

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Convolution neural network with batch normalization and inception-residual modules for Android malware classification

Abstract Deep learning technology is changing the landscape of cybersecurity research, especially the study of large amounts of data.With the rapid growth in the number of malware, developing of an efficient and camif commode reliable method for classifying malware has become one of the research priorities.In this paper, a new method, BIR-CNN, is p

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